Dianabol, also known as methandrostenolone (and/or methandienone), is an anabolic steroid widely used by bodybuilders and athletes today. It became popular in the late 1950s and was widely used during the “golden age of bodybuilding” in the 1960s and 1970s. Methandrostenolone was introduced to the scientific community by Dr. John Ziegler in the mid-1970s. 1950. It has been called the American response to the use of testosterone by Soviet Olympic athletes. Developed by Ziegler’s team, the drug was later introduced by Ciba under the brand name Dianabol. It was the first synthetic oral anabolic steroid sold on the prescription drug market.

The drug has a moderate estrogenic effect

The drug has a moderate estrogenic effect

The half-life of Dianabol is 4.5 to 6 hours. The drug has a moderate estrogenic effect and the rate of its conversion into a metabolite with more pronounced androgenic properties through the enzyme 5-alpha reductase is low. The benefits of Dianabol have made it popular among bodybuilders and athletes looking to increase muscle mass and strength.

Structure of Dianabol

Structure of Dianabol

The structure of Dianabol contains a 17 alpha methyl group. It is the C17-alpha alkylation that makes oral use of this anabolic steroid possible with a very noticeable effect on the body. Due to this modification, the compound does not undergo significant metabolism in the liver and a sufficient amount of anabolic steroid enters the bloodstream to obtain the full effect of this group of drugs. Another structural feature of Dianabol is the double bond between the carbon atoms at positions 1 and 2. Thanks to this modification, the drug has a “softer” androgenic power than its ancestor, testosterone. Because of this double bond, the drug’s affinity for androgen receptors in various tissues is less than that of testosterone. It is thanks to these structural changes that the half-life of Dianabol, which ranges between 4.5 and 6 hours, is higher compared to testosterone. Another advantage of these chemical transformations is the lower affinity of the drug for certain proteins, particularly sex hormone binding globulin (SHBG). These globulins bind to sex hormones such as testosterone, estrogen, and others, temporarily inhibiting their activity. The result of this process will be the formation of a protein-hormone complex that circulates in the bloodstream and is inactive, unable to bind to receptors or be active, and essentially useless. These characteristics of Dianabol give it the status of a powerful anabolic agent. It should be noted that the interaction of methandrostenolone with androgen receptors is weaker compared to testosterone and other members of the steroid group, but this hormone has a stronger and more powerful effect. Therefore, most of Dianabol’s effects are believed to be non-receptor mediated. At the same time, as you know, the anabolic index of Dianabol is 210, in contrast to the index of testosterone, which is 100. It is obvious that methandrostenolone has twice the anabolic power, and this is due to the structural modifications described previously.