Alpha-Lipoic Acid Supplements, Weight Loss & Obesity

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Research has found that the popular antioxidant supplement Alpha-Lipoic Acid may possess small but significant weight loss benefits and help to treat obesity.

Alpha-Lipoic Acid is a naturally occurring antioxidant, which is present in the mitochondria and is involved in energy metabolism.

Studies have already confirmed many impressive health benefits of Alpha-Lipoic Acid such as it’s ability to treat diabetic peripheral neuropathy, where it is commonly prescribed by physicians in Europe.

Alpha-Lipoic Acid may have other therapeutic benefits such as antioxidant properties, the ability to recycle antioxidants such as Vitamin C, E & Glutathione, improve insulin sensitivity, protect against metabolic syndrome, diabetes and atherosclerosis, chelate toxic heavy metals, reduce blood pressure, support the mitochondria and energy metabolism, boost levels of antixoidant glutathione, anti-inflammatory effect, improve endothelial dysfunction and much more.

Let’s take a look at some of the highlights from the current scientific research on Alpha-Lipoic Acid, weight loss and obesity.

A study from 2017 conducted a meta-analysis of the effect of ALA on weight and body mass index (BMI).

The results from a meta-analysis of randomized controlled trials concluded:

Alpha-lipoic acid treatment showed small, yet significant short-term weight loss compared with placebo. Further research is needed to examine the effect of different doses and the long-term benefits of ALA on weight management.

Another study published this year(2017) in the Journal of Clinical Nutrition(Edinburgh, Scotland) performed a systematic review and meta-analysis of clinical trials on the supplement Alpha-Lipoic Acid in obesity treatment.

The study concluded:

The present study revealed that supplementation with ALA slightly but significantly decreased body weight and BMI. Safe dosage for ALA is up to 1200 mg/day. However, it seems that ALA cannot be cost-effective. Further studies are needed to clarify the effects of ALA on metabolic parameter in unhealthy obese individuals.

Always consult a healthcare professional before taking any dietary supplements.


[1] Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials.

[2] Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials.

[3] Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases

The information in this article has not been evaluated by the FDA and should not be used to diagnose, cure or treat any disease, implied or otherwise.

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