A randomized, placebo-controlled study published in 2015 has found that a combination of the dietary supplements Co-Enzyme Q10 plus NADH, may significantly improve fatigue and other biochemical parameters for individuals with Chronic Fatigue Syndrome.
Chronic fatigue syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged fatigue and multiple symptoms with unknown cause, diagnostic test, or universally effective treatment.
Inflammation, oxidative stress, mitochondrial dysfunction, and Co-Enzyme Q10 deficiency have been well documented in CFS. 
We have blogged previously about the scientific research, which has found low plasma levels of Co-Enzyme Q10 to play a role in the pathophysiology of chronic fatigue syndrome.
The research found that Co-Enzyme Q10 deficiency was related to the chronic fatigue, autonomic and neurocognitive symptoms, typically seen in those with chronic fatigue syndrome.
The study also concluded that Co-Enzyme Q10 deficiency is an independent risk factor for developing chronic heart failure and early mortality, via cardiovascular disorder. Read more at: Co-Enzyme Q10 Deficiency & Chronic Fatigue Syndrome/ME
What is Co-Enzyme Q10 & NADH?
Co-Enzyme Q10 is a vitamin-like nutrient, which acts as an essential cofactor for the production of ATP in mitochondria.
Co-Enzyme Q10 also possesses significant antioxidant and anti-inflammatory properties.
NADH(Nicotinamide adenine dinucleotide) is the reduced coenzyme form of Vitamin B3(Niacin).
Nicotinamide adenine dinucleotide (NADH) may be depleted in chronic fatigue syndrome.
Administration of oral NADH was associated with a decrease in anxiety and maximum heart rate, after a stress test in patients with CFS. 
Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?
An 8-week, randomized, double-blind placebo-controlled trial was conducted to evaluate the benefits of oral CoQ10 (200 mg/day) plus NADH (20 mg/day) supplementation on fatigue and biochemical parameters in 73 Spanish CFS patients.
A significant improvement of fatigue showing a reduction in fatigue impact scale total score (p<0.05) was reported in treated group versus placebo.
In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p<0.001), CoQ10 (p<0.05), ATP (p<0.05), and citrate synthase (p<0.05) were significantly higher, and lipoperoxides (p<0.05) were significantly lower in blood mononuclear cells of the treated group.
These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confer potential therapeutic benefits on fatigue and biochemical parameters in CFS. Larger sample trials are warranted to confirm these findings.
 Does Oral Coenzyme Q10 Plus NADH Supplementation Improve Fatigue and Biochemical Parameters in Chronic Fatigue Syndrome?
 Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial.
 [Nicotinamide adenine dinucleotide (NADH) in patients with chronic fatigue syndrome].
The information in this article has not been evaluated by the FDA and should not be used to diagnose, cure or treat any disease, implied or otherwise.